CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family |
Enzyme Information
| 2.1.1.180 |
16S rRNA (adenine(1408)-N(1))-methyltransferase.
based on mapping to UniProt A8C927
S-adenosyl-L-methionine + adenine(1408) in 16S rRNA = S-adenosyl-L- homocysteine + N(1)-methyladenine(1408) in 16S rRNA.
-!- The enzyme provides a panaminoglycoside-resistant nature through interference with the binding of aminoglycosides toward the A site of 16S rRNA through N(1)-methylation at position adenine(1408).
|
UniProtKB Entries (3)
| A0A0N0BLP2 |
RS14Z_THEAQ
Thermus aquaticus
30S ribosomal protein S14 type Z
|
| A8C927 |
NPMA_ECOLX
Escherichia coli
16S rRNA (adenine(1408)-N(1))-methyltransferase
|
| Q5SJH3 |
RS16_THET8
Thermus thermophilus HB8
30S ribosomal protein S16
|
PDB Structure
| PDB | 4OX9 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA.
Proc.Natl.Acad.Sci.USA
|