CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family serine/threonine-protein kinase N2 isoform X1

Enzyme Information

2.7.11.13
Protein kinase C.
based on mapping to UniProt Q16512
ATP + a protein = ADP + a phosphoprotein.
-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q16512
PKN1_HUMAN
Homo sapiens
Serine/threonine-protein kinase N1

PDB Structure

PDB 4OTH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of PRK1 in Complex with the Clinical Compounds Lestaurtinib and Tofacitinib Reveal Ligand Induced Conformational Changes.
Chamberlain, P., Delker, S., Pagarigan, B., Mahmoudi, A., Jackson, P., Abbasian, M., Muir, J., Raheja, N., Cathers, B.
Plos One