CATH Classification

Domain Context

CATH Clusters

Superfamily 3.60.21.10
Functional Family Serine/threonine-protein phosphatase

Enzyme Information

3.1.3.16
Protein-serine/threonine phosphatase.
based on mapping to UniProt P63328
[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.
-!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).

UniProtKB Entries (1)

P63328
PP2BA_MOUSE
Mus musculus
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

PDB Structure

PDB 4ORB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Cooperative autoinhibition and multi-level activation mechanisms of calcineurin
Li, S.J., Ma, L., Wang, J., Lu, C., Wang, J., Wu, J.W., Wang, Z.X.
To be Published