CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.40
Functional Family

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P62942
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (3)

P0A7V3
RS3_ECOLI
Escherichia coli K-12
30S ribosomal protein S3
P62942
FKB1A_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase FKBP1A
Q5SLE7
Q5SLE7_THET8
Thermus thermophilus HB8
Peptidyl-prolyl cis-trans isomerase

PDB Structure

PDB 4ODQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD.
Quistgaard, E.M., Weininger, U., Ural-Blimke, Y., Modig, K., Nordlund, P., Akke, M., Low, C.
BMC Biol.