CATH Domain 4o1mA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

UniProtKB Entries (1)

Q6UCJ9_TOXGO

Toxoplasma gondii

Enoyl-acyl carrier reductase

PDB Structure

PDB	4O1M
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target Wilkinson, C., Mcphillie, M.J., Zhou, Y., Woods, S., Afanador, G.A., Rawson, S., Khaliq, F., Prigge, S.T., Roberts, C.W., Rice, D.W., Mcleod, R., Fishwick, C.W., Muench, S.P. Bioorg.Med.Chem.Lett.