CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.11950
Functional Family Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

Enzyme Information

2.7.4.24
Diphosphoinositol-pentakisphosphate kinase.
based on mapping to UniProt O43314
(1) ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate. (2) ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate.
-!- This enzyme is activated by osmotic shock. -!- Ins(1,3,4,5,6)P(5), 1D-myo-inositol diphosphate tetrakisphosphate and 1D-myo-inositol bisdiphosphate triphosphate are not substrates. -!- Formerly EC 2.7.1.155.
2.7.4.21
Inositol-hexakisphosphate kinase.
based on mapping to UniProt O43314
(1) ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate. (2) ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.
-!- Three mammalian isoforms are known to exist. -!- Formerly EC 2.7.1.152.

UniProtKB Entries (1)

O43314
VIP2_HUMAN
Homo sapiens
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

PDB Structure

PDB 4NZO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthetic Inositol Phosphate Analogs Reveal that PPIP5K2 Has a Surface-Mounted Substrate Capture Site that Is a Target for Drug Discovery.
Wang, H., Godage, H.Y., Riley, A.M., Weaver, J.D., Shears, S.B., Potter, B.V.
Chem.Biol.