CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Neutrophil elastase

Enzyme Information

3.4.21.37
Leukocyte elastase.
based on mapping to UniProt P08246
Hydrolysis of proteins, including elastin. Preferential cleavage: Val-|-Xaa > Ala-|-Xaa.
-!- Differs from pancreatic elastase in specificity on synthetic substrates and in inhibitor sensitivity. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.7 and EC 3.4.21.11.

UniProtKB Entries (2)

A0A0H3K0M1
A0A0H3K0M1_STAAM
Staphylococcus aureus subsp. aureus Mu50
Uncharacterized protein
P08246
ELNE_HUMAN
Homo sapiens
Neutrophil elastase

PDB Structure

PDB 4NZL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors.
Stapels, D.A., Ramyar, K.X., Bischoff, M., von Kockritz-Blickwede, M., Milder, F.J., Ruyken, M., Eisenbeis, J., McWhorter, W.J., Herrmann, M., van Kessel, K.P., Geisbrecht, B.V., Rooijakkers, S.H.
Proc.Natl.Acad.Sci.USA