CATH Classification

Domain Context

CATH Clusters

Superfamily Lipoxygenase-1; Domain 5
Functional Family Arachidonate 5-lipoxygenase a

Enzyme Information

1.13.11.33
Arachidonate 15-lipoxygenase.
based on mapping to UniProt O15296
Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa- 5,8,11,13-tetraenoate.
-!- The product is rapidly converted to the corresponding 15S-hydroxy compound.
1.13.11.-
With incorporation of two atoms of oxygen.
based on mapping to UniProt O15296

UniProtKB Entries (1)

O15296
LX15B_HUMAN
Homo sapiens
Arachidonate 15-lipoxygenase B

PDB Structure

PDB 4NRE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structure of human 15-lipoxygenase-2 with a substrate mimic.
Kobe, M.J., Neau, D.B., Mitchell, C.E., Bartlett, S.G., Newcomer, M.E.
J.Biol.Chem.