CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1460
Functional Family Legumain

Enzyme Information

3.4.22.34
Legumain.
based on mapping to UniProt O89017
Hydrolysis of proteins and small molecule substrates at -Asn-|- Xaa- bonds.
-!- Best known from legume seeds, the trematode Schistosoma mansoni and mammalian lysosomes. -!- Not inhibited by compound E-64. -!- Belongs to peptidase family C13.

UniProtKB Entries (1)

O89017
LGMN_MOUSE
Mus musculus
Legumain

PDB Structure

PDB 4NOL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage.
Zhao, L., Hua, T., Crowley, C., Ru, H., Ni, X., Shaw, N., Jiao, L., Ding, W., Qu, L., Hung, L.W., Huang, W., Liu, L., Ye, K., Ouyang, S., Cheng, G., Liu, Z.J.
Cell Res.