CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family 7-carboxy-7-deazaguanine synthase

Enzyme Information

4.3.99.3
7-carboxy-7-deazaguanine synthase.
based on mapping to UniProt A0A0H3KB22
6-carboxy-5,6,7,8-tetrahydropterin = 7-carboxy-7-carbaguanine + NH(3).
-!- The enzyme is a member of the superfamily of S-adenosyl-L-methionine- dependent radical (radical AdoMet) enzymes. -!- Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. -!- The S-adenosyl-L-methionine is catalytic as it is regenerated at the end of the reaction. -!- The reaction is part of the biosynthesis pathway of queuosine.

UniProtKB Entries (1)

A0A0H3KB22
QUEE_BURM1
Burkholderia multivorans ATCC 17616
7-carboxy-7-deazaguanine synthase

PDB Structure

PDB 4NJG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism.
Dowling, D.P., Bruender, N.A., Young, A.P., McCarty, R.M., Bandarian, V., Drennan, C.L.
Nat.Chem.Biol.