CATH Domain 4n7eA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.10	Ribbon
	2.10.70	Complement Module; domain 1
	2.10.70.80	Sortilin Vps10-D, 10CC-a domain

Domain Context

CATH Clusters

Superfamily	2.10.70.80
Functional Family	Sortilin

Enzyme Information

UniProtKB Entries (1)

SORT_HUMAN

Homo sapiens

Sortilin

PDB Structure

PDB	4N7E
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Schrder, T.J., Christensen, S., Lindberg, S., Langgard, M., David, L., Maltas, P.J., Eskildsen, J., Jacobsen, J., Tagmose, L., Simonsen, K.B., Biilmann Rnn, L.C., de Jong, I.E., Malik, I.J., Karlsson, J.J., Bundgaard, C., Egebjerg, J., Stavenhagen, J.B., Strandbygard, D., Thirup, S., Andersen, J.L., Uppalanchi, S., Pervaram, S., Kasturi, S.P., Eradi, P., Sakumudi, D.R., Watson, S.P. Bioorg.Med.Chem.Lett.