CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Hepatocyte growth factor receptor

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P08581
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P08581
MET_HUMAN
Homo sapiens
Hepatocyte growth factor receptor

PDB Structure

PDB 4MXC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of Anilinopyrimidines as Dual Inhibitors of c-Met and VEGFR-2: Synthesis, SAR, and Cellular Activity
Zhan, Z.S., Ai, J., Liu, Q.F., Ji, Y.C., Chen, T.T., Xu, Y.C., Geng, M.Y., Duan, W.H.
ACS MED.CHEM.LETT.