CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase ITK/TSK

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q08881
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q08881
ITK_HUMAN
Homo sapiens
Tyrosine-protein kinase ITK/TSK

PDB Structure

PDB 4M14
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.
Han, S., Czerwinski, R.M., Caspers, N.L., Limburg, D.C., Ding, W., Wang, H., Ohren, J.F., Rajamohan, F., McLellan, T.J., Unwalla, R., Choi, C., Parikh, M.D., Seth, N., Edmonds, J., Phillips, C., Shakya, S., Li, X., Spaulding, V., Hughes, S., Cook, A., Robinson, C., Mathias, J.P., Navratilova, I., Medley, Q.G., Anderson, D.R., Kurumbail, R.G., Aulabaugh, A.
Biochem.J.