CATH Classification

Domain Context

CATH Clusters

Superfamily Aldehyde Dehydrogenase; Chain A, domain 2
Functional Family Mitochondrial aldehyde dehydrogenase 2

Enzyme Information

1.2.1.3
Aldehyde dehydrogenase (NAD(+)).
based on mapping to UniProt P05091
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
-!- Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. -!- Formerly EC 1.1.1.70.

UniProtKB Entries (1)

P05091
ALDH2_HUMAN
Homo sapiens
Aldehyde dehydrogenase, mitochondrial

PDB Structure

PDB 4KWF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones.
Kimble-Hill, A.C., Parajuli, B., Chen, C.H., Mochly-Rosen, D., Hurley, T.D.
J.Med.Chem.