CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.1410.40
Functional Family Cyclic GMP-AMP synthase

Enzyme Information

2.7.7.86
Cyclic GMP-AMP synthase.
based on mapping to UniProt Q8C6L5
ATP + GTP = 2 diphosphate + cyclic G-P(2'-5')A-P(3'-5').
-!- Cyclic Gp(2'-5')Ap(3'-5') is a signaling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.

UniProtKB Entries (1)

Q8C6L5
CGAS_MOUSE
Mus musculus
Cyclic GMP-AMP synthase

PDB Structure

PDB 4K96
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Gao, P., Ascano, M., Wu, Y., Barchet, W., Gaffney, B.L., Zillinger, T., Serganov, A.A., Liu, Y., Jones, R.A., Hartmann, G., Tuschl, T., Patel, D.J.
Cell(Cambridge,Mass.)