CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrodipicolinate Reductase; domain 2
Functional Family

Enzyme Information

1.2.1.10
Acetaldehyde dehydrogenase (acetylating).
based on mapping to UniProt P9WQH3
Acetaldehyde + CoA + NAD(+) = acetyl-CoA + NADH.
-!- Also acts, more slowly, on glycolaldehyde, propanal and butanal. -!- In several bacterial species this enzyme forms a bifunctional complex with EC 4.1.3.39. -!- The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 1.2.1.87. -!- Involved in the meta-cleavage pathway for the degradation of phenols, methylphenols and catechols. -!- NADP(+) can replace NAD(+) but the rate of reaction is much slower.

UniProtKB Entries (1)

P9WMK5
HOA_MYCTU
Mycobacterium tuberculosis H37Rv
4-hydroxy-2-oxovalerate aldolase

PDB Structure

PDB 4JN6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Characterization of an Aldolase-Dehydrogenase Complex from the Cholesterol Degradation Pathway of Mycobacterium tuberculosis.
Carere, J., McKenna, S.E., Kimber, M.S., Seah, S.Y.
Biochemistry