CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.460.90
Functional Family Cyclic GMP-AMP synthase

Enzyme Information

2.7.7.86
Cyclic GMP-AMP synthase.
based on mapping to UniProt I3LM39
ATP + GTP = 2 diphosphate + cyclic G-P(2'-5')A-P(3'-5').
-!- Cyclic Gp(2'-5')Ap(3'-5') is a signaling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.

UniProtKB Entries (1)

I3LM39
CGAS_PIG
Sus scrofa
Cyclic GMP-AMP synthase

PDB Structure

PDB 4JLZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural mechanism of cytosolic DNA sensing by cGAS
Civril, F., Deimling, T., Mann, C.C.O., Ablasser, A., Moldt, M., Witte, G., Hornung, V., Hopfner, K.P.
Nature