CATH Classification

Domain Context

CATH Clusters

Superfamily 2.120.10.10
Functional Family Hemagglutinin-neuraminidase

Enzyme Information

3.2.1.18
Exo-alpha-sialidase.
based on mapping to UniProt P04850
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

P04850
HN_PIV5
Simian virus 5 (strain W3)
Hemagglutinin-neuraminidase

PDB Structure

PDB 4JF7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the Parainfluenza Virus 5 (PIV5) Hemagglutinin-Neuraminidase (HN) Ectodomain.
Welch, B.D., Yuan, P., Bose, S., Kors, C.A., Lamb, R.A., Jardetzky, T.S.
Plos Pathog.