CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Mitogen-activated protein kinase

Enzyme Information

2.7.11.24
Mitogen-activated protein kinase.
based on mapping to UniProt P28482
ATP + a protein = ADP + a phosphoprotein.
-!- Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2 is necessary for enzyme activation. -!- Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline. -!- A distinguishing feature of all MAPKs is the conserved sequence Thr- Xaa-Tyr (TXY). -!- Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. -!- Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q15121
PEA15_HUMAN
Homo sapiens
Astrocytic phosphoprotein PEA-15

PDB Structure

PDB 4IZA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.
Mace, P.D., Wallez, Y., Egger, M.F., Dobaczewska, M.K., Robinson, H., Pasquale, E.B., Riedl, S.J.
Nat Commun