CATH Classification

Domain Context

CATH Clusters

Superfamily TolB, C-terminal domain
Functional Family

Enzyme Information

4.3.3.2
Strictosidine synthase.
based on mapping to UniProt P68175
3-alpha-(S)-strictosidine + H(2)O = tryptamine + secologanin.
-!- Catalyzes a a Pictet-Spengler reaction between the aldehyde group of secologanin and the amino group of tryptamine. -!- Involved in the biosynthesis of the monoterpenoid indole alkaloids.

UniProtKB Entries (1)

P68175
STSY_RAUSE
Rauvolfia serpentina
Strictosidine synthase

PDB Structure

PDB 4IYG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Using Strictosidine Synthase to Prepare Novel Alkaloids.
Zhu, H., Kercmar, P., Wu, F., Rajendran, C., Sun, L., Wang, M., Stockigt, J.
Curr.Med.Chem.