CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphoenolpyruvate-binding domains
Functional Family Pyruvate kinase

Enzyme Information

2.7.1.40
Pyruvate kinase.
based on mapping to UniProt P30613
ATP + pyruvate = ADP + phosphoenolpyruvate.
-!- UTP, GTP, CTP, ITP and dATP can also act as donors. -!- Also phosphorylates hydroxylamine and fluoride in the presence of CO(2).

UniProtKB Entries (1)

P30613
KPYR_HUMAN
Homo sapiens
Pyruvate kinase PKLR

PDB Structure

PDB 4IP7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Energetic Coupling between an Oxidizable Cysteine and the Phosphorylatable N-Terminus of Human Liver Pyruvate Kinase.
Holyoak, T., Zhang, B., Deng, J., Tang, Q., Prasannan, C.B., Fenton, A.W.
Biochemistry