CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family

Enzyme Information

2.6.1.51
Serine--pyruvate transaminase.
based on mapping to UniProt P21549
L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.
-!- The liver enzyme may be identical with EC 2.6.1.44.
2.6.1.44
Alanine--glyoxylate transaminase.
based on mapping to UniProt P21549
L-alanine + glyoxylate = pyruvate + glycine.
-!- With one component of the animal enzyme, 2-oxobutanoate can replace glyoxylate. -!- A second component also catalyzes the reaction of EC 2.6.1.51.

UniProtKB Entries (1)

P21549
SPYA_HUMAN
Homo sapiens
Serine--pyruvate aminotransferase

PDB Structure

PDB 4I8A
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the S187F variant of human liver alanine: Aminotransferase associated with primary hyperoxaluria type I and its functional implications.
Oppici, E., Fodor, K., Paiardini, A., Williams, C., Voltattorni, C.B., Wilmanns, M., Cellini, B.
Proteins