CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Renin

Enzyme Information

3.4.23.15
Renin.
based on mapping to UniProt P00797
Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.
-!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.15 and EC 3.4.99.19.

UniProtKB Entries (1)

P00797
RENI_HUMAN
Homo sapiens
Renin

PDB Structure

PDB 4GJB
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A novel class of oral direct Renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.
Ostermann, N., Ruedisser, S., Ehrhardt, C., Breitenstein, W., Marzinzik, A., Jacoby, E., Vangrevelinghe, E., Ottl, J., Klumpp, M., Hartwieg, J.C., Cumin, F., Hassiepen, U., Trappe, J., Sedrani, R., Geisse, S., Gerhartz, B., Richert, P., Francotte, E., Wagner, T., Kromer, M., Kosaka, T., Webb, R.L., Rigel, D.F., Maibaum, J., Baeschlin, D.K.
J.Med.Chem.