CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Thymidylate kinase

Enzyme Information

2.7.4.9
dTMP kinase.
based on mapping to UniProt P65248
ATP + dTMP = ADP + dTDP.

UniProtKB Entries (1)

P65248
KTHY_STAAM
Staphylococcus aureus subsp. aureus Mu50
Thymidylate kinase

PDB Structure

PDB 4GFD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound.
Keating, T.A., Newman, J.V., Olivier, N.B., Otterson, L.G., Andrews, B., Boriack-Sjodin, P.A., Breen, J.N., Doig, P., Dumas, J., Gangl, E., Green, O.M., Guler, S.Y., Hentemann, M.F., Joseph-McCarthy, D., Kawatkar, S., Kutschke, A., Loch, J.T., McKenzie, A.R., Pradeepan, S., Prasad, S., Martinez-Botella, G.
Acs Chem.Biol.