CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P0AD64
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P0AD64
BLA1_KLEPN
Klebsiella pneumoniae
Beta-lactamase SHV-1

PDB Structure

PDB 4GD8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of SHV-1 beta-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation
Ke, W., Pattanaik, P., Bethel, C.R., Sheri, A., Buynak, J.D., Bonomo, R.A., van den Akker, F.
Plos One