CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Enzyme Information

1.1.1.267
1-deoxy-D-xylulose-5-phosphate reductoisomerase.
based on mapping to UniProt O96693
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH.
-!- The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis. -!- The mechanism has been shown to be a retroaldol/aldol reaction.

UniProtKB Entries (1)

O96693
DXR_PLAFX
Plasmodium falciparum HB3
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic

PDB Structure

PDB 4GAE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Antimalarial and Structural Studies of Pyridine-containing Inhibitors of 1-Deoxyxylulose-5-phosphate Reductoisomerase.
Xue, J., Diao, J., Cai, G., Deng, L., Zheng, B., Yao, Y., Song, Y.
ACS Med Chem Lett