CATH Classification

Domain Context

CATH Clusters

Superfamily Farnesyl Diphosphate Synthase
Functional Family Farnesyl pyrophosphate synthase

Enzyme Information

2.5.1.1
Dimethylallyltranstransferase.
based on mapping to UniProt P14324
Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
-!- Will not accept larger prenyl diphosphates as efficient donors.
2.5.1.10
(2E,6E)-farnesyl diphosphate synthase.
based on mapping to UniProt P14324
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)- farnesyl diphosphate.
-!- Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. -!- The enzyme will not accept larger prenyl diphosphates as efficient donors.

UniProtKB Entries (1)

P14324
FPPS_HUMAN
Homo sapiens
Farnesyl pyrophosphate synthase

PDB Structure

PDB 4GA3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Chemo-Immunotherapeutic Anti-Malarials Targeting Isoprenoid Biosynthesis.
Zhang, Y., Zhu, W., Liu, Y.L., Wang, H., Wang, K., Li, K., No, J.H., Ayong, L., Gulati, A., Pang, R., Freitas-Junior, L., Morita, C.T., Old-Field, E.
ACS MED.CHEM.LETT.