CATH Classification

Domain Context

CATH Clusters

Superfamily Heme oxygenase-like
Functional Family Heme oxygenase 1

Enzyme Information

1.14.14.18
Heme oxygenase (biliverdin-producing).
based on mapping to UniProt P06762
Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) = biliverdin + Fe(2+) + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H(2)O.
-!- This mammalian enzyme participates in the degradation of heme. -!- The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules. -!- The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO. -!- The enzyme requires NAD(P)H and EC 1.6.2.4. -!- Cf. EC 1.14.15.20. -!- Formerly EC 1.14.99.3.

UniProtKB Entries (1)

P06762
HMOX1_RAT
Rattus norvegicus
Heme oxygenase 1

PDB Structure

PDB 4G8U
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discrimination between CO and O2 in Heme Oxygenase: Comparison of Static Structures and Dynamic Conformation Changes following CO Photolysis
Sugishima, M., Moffat, K., Noguchi, M.
Biochemistry