CATH Classification

Domain Context

CATH Clusters

Superfamily Haem peroxidase domain superfamily, animal type
Functional Family Prostaglandin G/H synthase 2

Enzyme Information

1.14.99.1
Prostaglandin-endoperoxide synthase.
based on mapping to UniProt Q05769
Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.
-!- Acts both as a dioxygenase and as a peroxidase.

UniProtKB Entries (1)

Q05769
PGH2_MOUSE
Mus musculus
Prostaglandin G/H synthase 2

PDB Structure

PDB 4FM5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes.
Windsor, M.A., Hermanson, D.J., Kingsley, P.J., Xu, S., Crews, B.C., Ho, W., Keenan, C.M., Banerjee, S., Sharkey, K.A., Marnett, L.J.
ACS Med Chem Lett