CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Cell division protein kinase 5

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt P24941
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P24941
CDK2_HUMAN
Homo sapiens
Cyclin-dependent kinase 2

PDB Structure

PDB 4FKG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the cdk2 in complex with aminopyrazole inhibitor
Kang, Y.N., Stuckey, J.A.
To be Published