CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P0AD64
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P0AD64
BLA1_KLEPN
Klebsiella pneumoniae
Beta-lactamase SHV-1

PDB Structure

PDB 4FCF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design and exploration of novel boronic acid inhibitors reveals important interactions with a clavulanic acid-resistant sulfhydryl-variable (SHV) beta-lactamase.
Winkler, M.L., Rodkey, E.A., Taracila, M.A., Drawz, S.M., Bethel, C.R., Papp-Wallace, K.M., Smith, K.M., Xu, Y., Dwulit-Smith, J.R., Romagnoli, C., Caselli, E., Prati, F., van den Akker, F., Bonomo, R.A.
J.Med.Chem.