CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.10 Ribbon
Topology 2.10.60 CD59
Homologous Superfamily 2.10.60.10 CD59

Domain Context

CATH Clusters

Superfamily CD59
Functional Family Serine/threonine-protein kinase receptor R3

Enzyme Information

2.7.11.30
Receptor protein serine/threonine kinase.
based on mapping to UniProt P37023
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P37023
ACVL1_HUMAN
Homo sapiens
Serine/threonine-protein kinase receptor R3

PDB Structure

PDB 4FAO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex.
Townson, S.A., Martinez-Hackert, E., Greppi, C., Lowden, P., Sako, D., Liu, J., Ucran, J.A., Liharska, K., Underwood, K.W., Seehra, J., Kumar, R., Grinberg, A.V.
J.Biol.Chem.