CATH Classification

Domain Context

CATH Clusters

Superfamily NADP-dependent oxidoreductase domain
Functional Family Aldo-keto reductase family 1 member C3

Enzyme Information

1.1.1.188
Prostaglandin-F synthase.
based on mapping to UniProt P42330
(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH.
-!- Reduces prostaglandin D(2) and prostaglandin H(2) to prostaglandin F(2); prostaglandin D(2) is not an intermediate in the reduction of prostaglandin H(2). -!- Also catalyzes the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone.
1.1.1.112
Indanol dehydrogenase.
based on mapping to UniProt P42330
Indan-1-ol + NAD(P)(+) = indanone + NAD(P)H.
-!- 3(20)-alpha-hydroxysteroids are also oxidized, more slowly.
1.3.1.20
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase.
based on mapping to UniProt P42330
Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH.
1.1.1.239
3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)).
based on mapping to UniProt P42330
Testosterone + NAD(+) = androstenedione + NADH.
-!- Also acts on other 17-beta-hydroxysteroids, on the 3-alpha-hydroxy group of pregnanes and bile acids. -!- Different from EC 1.1.1.50 or EC 1.1.1.213. -!- Formerly EC 1.1.1.63.
1.1.1.357
3-alpha-hydroxysteroid 3-dehydrogenase.
based on mapping to UniProt P42330
A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3-oxosteroid + NAD(P)H.
-!- The enzyme acts on multiple 3-alpha-hydroxysteroids, such as androsterone and 5 alpha-dihydrotestosterone. -!- The mammalian enzymes are involved in inactivation of steroid hormones, while the bacterial enzymes are involved in steroid degradation. -!- This entry stands for enzymes whose stereo-specificity with respect to NAD(+) or NADP(+) is not known (cf. EC 1.1.1.50 and EC 1.1.1.213).
1.-.-.-
Oxidoreductases.
based on mapping to UniProt P42330
1.1.1.64
Testosterone 17-beta-dehydrogenase (NADP(+)).
based on mapping to UniProt P42330
Testosterone + NADP(+) = androst-4-ene-3,17-dione + NADPH.
-!- Also oxidizes 3-hydroxyhexobarbital to 3-oxohexobarbital.

UniProtKB Entries (1)

P42330
AK1C3_HUMAN
Homo sapiens
Aldo-keto reductase family 1 member C3

PDB Structure

PDB 4FAL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic acids; a New Class of Highly Potent and Selective Inhibitors of the Type 5 17-beta-hydroxysteroid Dehydrogenase AKR1C3
Jamieson, S.M., Brooke, D.G., Heinrich, D., Atwell, G.J., Silva, S., Hamilton, E.J., Turnbull, A.P., Rigoreau, L.J., Trivier, E., Soudy, C., Samlal, S.S., Owen, P.J., Schroeder, E., Raynham, T., Flanagan, J.U., Denny, W.A.
J.Med.Chem.