CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family Aspartate aminotransferase

Enzyme Information

2.6.1.1
Aspartate transaminase.
based on mapping to UniProt P00509
L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
-!- Also acts on L-tyrosine, L-phenylalanine and L-tryptophan. -!- This activity can be formed from EC 2.6.1.57 by controlled proteolysis.

UniProtKB Entries (1)

P00509
AAT_ECOLI
Escherichia coli K-12
Aspartate aminotransferase

PDB Structure

PDB 4F5J
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Janus: prediction and ranking of mutations required for functional interconversion of enzymes.
Addington, T.A., Mertz, R.W., Siegel, J.B., Thompson, J.M., Fisher, A.J., Filkov, V., Fleischman, N.M., Suen, A.A., Zhang, C., Toney, M.D.
J.Mol.Biol.