CATH Classification

Domain Context

CATH Clusters

Superfamily paz domain
Functional Family Protein argonaute-2

Enzyme Information

3.1.26.n2
Argonaute-2.
based on mapping to UniProt Q9UKV8
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- The enzyme, isolated from animals, is required for RNA-mediated gene silencing (RNAi).

UniProtKB Entries (1)

Q9UKV8
AGO2_HUMAN
Homo sapiens
Protein argonaute-2

PDB Structure

PDB 4F3T
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Structure of Human Argonaute-2 in Complex with miR-20a.
Elkayam, E., Kuhn, C.D., Tocilj, A., Haase, A.D., Greene, E.M., Hannon, G.J., Joshua-Tor, L.
Cell(Cambridge,Mass.)