CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Cyclin-dependent kinase 2

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt P24941
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P20248
CCNA2_HUMAN
Homo sapiens
Cyclin-A2

PDB Structure

PDB 4EOK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
An integrated chemical biology approach provides insight into Cdk2 functional redundancy and inhibitor sensitivity.
Echalier, A., Cot, E., Camasses, A., Hodimont, E., Hoh, F., Jay, P., Sheinerman, F., Krasinska, L., Fisher, D.
Chem.Biol.