CATH Classification

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family 1,4-dihydroxy-2-naphthoyl-CoA synthase

Enzyme Information

4.1.3.36
1,4-dihydroxy-2-naphthoyl-CoA synthase.
based on mapping to UniProt P0ABU0
4-(2-carboxyphenyl)-4-oxobutanoyl-CoA = 1,4-dihydroxy-2-naphthoyl-CoA + H(2)O.
-!- This enzyme is involved in the synthesis of 1,4-dihydroxy-2- naphthoate, a branch point metabolite leading to the biosynthesis of menaquinone (vitamin K(2), in bacteria), phylloquinone (vitamin K(1) in plants), and many plant pigments. -!- The coenzyme A group is subsequently removed from the product by EC 3.1.2.28.

UniProtKB Entries (1)

P0ABU0
MENB_ECOLI
Escherichia coli K-12
1,4-dihydroxy-2-naphthoyl-CoA synthase

PDB Structure

PDB 4ELX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Active site binding and catalytic role of bicarbonate in 1,4-dihydroxy-2-naphthoyl coenzyme A synthases from vitamin K biosynthetic pathways
Sun, Y.R., Song, H.G., Li, J., Jiang, M., Li, Y., Zhou, J.H., Guo, Z.H.
Biochemistry