CATH Domain 4ehiA03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.140	Cytidine Deaminase; domain 2
	3.40.140.20	AICAR transformylase, duplication domain

Domain Context

CATH Clusters

Superfamily	3.40.140.20
Functional Family	Bifunctional purine biosynthesis protein PurH

Enzyme Information

3.5.4.10	IMP cyclohydrolase. based on mapping to UniProt Q9PNY2 IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
2.1.2.3	Phosphoribosylaminoimidazolecarboxamide formyltransferase. based on mapping to UniProt Q9PNY2 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.

UniProtKB Entries (1)

PUR9_CAMJE

Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

Bifunctional purine biosynthesis protein PurH

PDB Structure

PDB	4EHI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	An X-ray Crystal Structure of a putative Bifunctional Phosphoribosylaminoimidazolecarboxamide Formyltransferase/IMP Cyclohydrolase Brunzelle, J.S., Wawrzak, Z., Onopriyenko, O., Kwok, J., Anderson, W.F., Savchenko, A., Center for Structural Genomics of Infectious Diseases TO BE PUBLISHED