CATH Domain 4eb5A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1150	Aspartate Aminotransferase, domain 1
	3.90.1150.10	Aspartate Aminotransferase, domain 1

Domain Context

CATH Clusters

Superfamily	Aspartate Aminotransferase, domain 1
Functional Family

Enzyme Information

2.8.1.7

Cysteine desulfurase.

based on mapping to UniProt O29689

L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor.

-!- The sulfur from free L-cysteine is first transferred to a cysteine residue in the active site, and then passed on to various other acceptors. -!- The enzyme is involved in the biosynthesis of iron-sulfur clusters, thio-nucleosides in tRNA, thiamine, biotin, lipoate and pyranopterin (molybdopterin). -!- In Azotobacter vinelandii, this sulfur provides the inorganic sulfide required for nitrogenous metallocluster formation.

UniProtKB Entries (1)

O29689

ISCS2_ARCFU

Archaeoglobus fulgidus DSM 4304

Cysteine desulfurase IscS 2

PDB Structure

PDB	4EB5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	(IscS-IscU)2 complex structures provide insights into Fe2S2 biogenesis and transfer. Marinoni, E.N., de Oliveira, J.S., Nicolet, Y., Raulfs, E.C., Amara, P., Dean, D.R., Fontecilla-Camps, J.C. Angew.Chem.Int.Ed.Engl.