CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P07332
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P07332
FES_HUMAN
Homo sapiens
Tyrosine-protein kinase Fes/Fps

PDB Structure

PDB 4E93
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Small-Molecule Inhibitors of the c-Fes Protein-Tyrosine Kinase.
Hellwig, S., Miduturu, C.V., Kanda, S., Zhang, J., Filippakopoulos, P., Salah, E., Deng, X., Choi, H.G., Zhou, W., Hur, W., Knapp, S., Gray, N.S., Smithgall, T.E.
Chem.Biol.