CATH Classification

Domain Context

CATH Clusters

Superfamily Beta Polymerase, domain 2
Functional Family DNA polymerase beta

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P06746
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
4.2.99.-
Other carbon-oxygen lyases.
based on mapping to UniProt P06746

UniProtKB Entries (1)

P06746
DPOLB_HUMAN
Homo sapiens
DNA polymerase beta

PDB Structure

PDB 4DO9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Beta,gamma-CHF- and beta,gamma-CHCl-dGTP Diastereomers: Synthesis, Discrete (31)P NMR Signatures, and Absolute Configurations of New Stereochemical Probes for DNA Polymerases
Wu, Y., Zakharova, V.M., Kashemirov, B.A., Goodman, M.F., Batra, V.K., Wilson, S.H., McKenna, C.E.
J.Am.Chem.Soc.