CATH Classification

Domain Context

CATH Clusters

Superfamily Cyclophilin-like
Functional Family Peptidyl-prolyl cis-trans isomerase A

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P62940
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P62940
PPIA_MACMU
Macaca mulatta
Peptidyl-prolyl cis-trans isomerase A

PDB Structure

PDB 4DGC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Diverse HIV viruses are targeted by a conformationally dynamic antiviral.
Caines, M.E., Bichel, K., Price, A.J., McEwan, W.A., Towers, G.J., Willett, B.J., Freund, S.M., James, L.C.
Nat.Struct.Mol.Biol.