CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family

Enzyme Information

2.6.1.51
Serine--pyruvate transaminase.
based on mapping to UniProt P21549
L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.
-!- The liver enzyme may be identical with EC 2.6.1.44.
2.6.1.44
Alanine--glyoxylate transaminase.
based on mapping to UniProt P21549
L-alanine + glyoxylate = pyruvate + glycine.
-!- With one component of the animal enzyme, 2-oxobutanoate can replace glyoxylate. -!- A second component also catalyzes the reaction of EC 2.6.1.51.

UniProtKB Entries (1)

P21549
SPYA_HUMAN
Homo sapiens
Serine--pyruvate aminotransferase

PDB Structure

PDB 4CBR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Consensus-Based Approach for Gene/Enzyme Replacement Therapies and Crystallization Strategies: The Case of Human Alanine:Glyoxylate Aminotransferase.
Mesa-Torres, N., Yunta, C., Fabelo-Rosa, I., Gonzalez-Rubio, J.M., Sanchez-Ruiz, J.M., Salido, E., Albert, A., Pey, A.L.
Biochem.J.