CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoplasmin core domain
Functional Family 39 kDa FK506-binding nuclear protein

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P54397
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P54397
FKB39_DROME
Drosophila melanogaster
39 kDa FK506-binding nuclear protein

PDB Structure

PDB 4CA9
External Links
Method SOLUTION NMR
Organism
Primary Citation
The Pentameric Nucleoplasmin Fold is Present in Drosophila Fkbp39 and a Large Number of Chromatin-Related Proteins.
Edlich-Muth, C., Artero, J., Callow, P., Przewloka, M.R., Watson, A.A., Zhang, W., Glover, D.M., Debski, J., Dadlez, M., Round, A.R., Trevor Forsyth, V., Laue, E.D.
J.Mol.Biol.