CATH Classification

Domain Context

CATH Clusters

Superfamily HAD superfamily/HAD-like
Functional Family Pyridoxal phosphate phosphatase

Enzyme Information

3.1.3.74
Pyridoxal phosphatase.
based on mapping to UniProt P60487
Pyridoxal 5'-phosphate + H(2)O = pyridoxal + phosphate.
-!- Specific for phosphorylated vitamin B(6) compounds: it acts not only on pyridoxal phosphate (PLP), but also on pyridoxine phosphate (PNP), pyridoxamine phosphate (PMP), 4-pyridoxic acid phosphate and 4-deoxypyridoxine phosphate. -!- This reaction can also be carried out by EC 3.1.3.1 and EC 3.1.3.2, but these enzymes have very broad substrate specificities.
3.1.3.3
Phosphoserine phosphatase.
based on mapping to UniProt P60487
O-phospho-L(or D)-serine + H(2)O = L(or D)-serine + phosphate.

UniProtKB Entries (1)

P60487
PLPP_MOUSE
Mus musculus
Pyridoxal phosphate phosphatase

PDB Structure

PDB 4BX2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Chronophin Dimerization is Required for Proper Positioning of its Substrate Specificity Loop.
Kestler, C., Knobloch, G., Tessmer, I., Jeanclos, E., Schindelin, H., Gohla, A.
J.Biol.Chem.