CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Focal adhesion kinase, isoform D

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q00944
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q00944
FAK1_CHICK
Gallus gallus
Focal adhesion kinase 1

PDB Structure

PDB 4BRX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Synthesis of Novel Diarylamino-1,3,5-Triazine Derivatives as Fak Inhibitors with Anti-Angiogenic Activity.
Dao, P., Jarray, R., Le Coq, J., Lietha, D., Loukaci, A., Lepelletier, Y., Hadj-Slimane, R., Garbay, C., Raynaud, F., Chen, H.
Bioorg.Med.Chem.Lett.