CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family 3-oxoacyl-[acyl-carrier-protein] reductase FabG

Enzyme Information

1.1.1.100
3-oxoacyl-[acyl-carrier-protein] reductase.
based on mapping to UniProt O54438
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl- carrier-protein] + NADPH.
-!- Exhibits a marked preference for [acyl-carrier-protein] derivatives over CoA derivatives as substrates.

UniProtKB Entries (1)

O54438
FABG_PSEAE
Pseudomonas aeruginosa PAO1
3-oxoacyl-[acyl-carrier-protein] reductase FabG

PDB Structure

PDB 4BO1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-Acyl-Acp Reductase from Pseudomonas Aeruginosa
Cukier, C.D., Hope, A., Elamin, A., Moynie, L., Schnell, R., Schach, S., Kneuper, H., Singh, M., Naismith, J., Lindqvist, Y., Gray, D., Schneider, G.
Acs Chem.Biol.