CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Mitogen-activated protein kinase

Enzyme Information

2.7.11.24
Mitogen-activated protein kinase.
based on mapping to UniProt Q13164
ATP + a protein = ADP + a phosphoprotein.
-!- Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2 is necessary for enzyme activation. -!- Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline. -!- A distinguishing feature of all MAPKs is the conserved sequence Thr- Xaa-Tyr (TXY). -!- Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. -!- Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q13164
MK07_HUMAN
Homo sapiens
Mitogen-activated protein kinase 7

PDB Structure

PDB 4B99
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
X-Ray Crystal Structure of Erk5 (Mapk7) in Complex with a Specific Inhibitor.
Elkins, J.M., Wang, J., Deng, X., Pattison, M.J., Arthur, S., Erazo, T., Gomez, N., Lizcano, J.M., Gray, N.S., Knapp, S.
J.Med.Chem.