CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Bifunctional protein FolD

Enzyme Information

3.5.4.9
Methenyltetrahydrofolate cyclohydrolase.
based on mapping to UniProt D0CBC8
5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.
1.5.1.5
Methylenetetrahydrofolate dehydrogenase (NADP(+)).
based on mapping to UniProt D0CBC8
5,10-methylenetetrahydrofolate + NADP(+) = 5,10- methenyltetrahydrofolate + NADPH.

UniProtKB Entries (1)

D0CBC8
D0CBC8_ACIB2
Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841
Bifunctional protein FolD

PDB Structure

PDB 4B4W
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Acinetobacter Baumannii Fold Ligand Complexes; Potent Inhibitors of Folate Metabolism and a Re-Evaluation of the Ly374571 Structure.
Eadsforth, T.C., Maluf, F.V., Hunter, W.N.
FEBS J.