CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family Carboxypeptidase

Enzyme Information

3.4.16.5
Carboxypeptidase C.
based on mapping to UniProt P10619
Release of a C-terminal amino acid with broad specificity.
-!- Carboxypeptidases of broad specificity with optimum pH 4.5-6.0, inhibited by the action of diisopropyl fluorophosphate, and sensitive to thiol-blocking reagents. -!- This enzyme is probably also identical to lysosomal tyrosine carboxypeptidase. -!- Belongs to peptidase family S10. -!- Formerly EC 3.4.12.1, EC 3.4.12.12, EC 3.4.16.1, EC 3.4.16.3 and EC 3.4.21.13.

UniProtKB Entries (1)

P10619
PPGB_HUMAN
Homo sapiens
Lysosomal protective protein

PDB Structure

PDB 4AZ0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Novel Beta-Amino Acid Derivatives as Inhibitors of Cathepsin A.
Ruf, S., Buning, C., Schreuder, H., Horstick, G., Linz, W., Olpp, T., Pernerstorfer, J., Hiss, K., Kroll, K., Kannt, A., Kohlmann, M., Linz, D., Hubschle, T., Rutten, H., Wirth, K., Schmidt, T., Sadowski, T.
J.Med.Chem.